Contribution of trifluoperazine metabolites to the in vivo F-19 NMR spectrum of rat brain

Fluorine-19 NMR spectra were acquired from extracts of tissues from heads o f rats given the antipsychotic drug trifluoperazine (TFP). Contributions to the in vivo F-19 spectra from tissues other than brain were negligible. Th e in vivo F-19 resonance at -62.3 ppm from CCI3F consisted of 6-8 resolved resonances in vitro. Some in vitro resonances were assigned to previously i dentified TFP metabolites. Multiple resonances in vitro partially explain t he relatively large line width seen in vivo for TFP, Unidentified metabolit es were observed at about -74 to -75 ppm in a number of spectra of extracts of brain and muscle. Magn Reson Med 43:756-759, 2000. (C) 2000 Wiley-Liss, Inc.