Mj. Conceicao et al., Study of Schistosoma mansoni isolates from patients with failure of treatment with oxamniquine, MEM I OSW C, 95(3), 2000, pp. 375-380
After three successive treatments with oxamniquine the continuing eliminati
on of Schistosoma mansoni eggs was observed inpatients, who came from vario
us regions of Brazil, with different clinical forms of schistosomiasis. The
objective of the present study was to determine the experimental behaviour
of five different S. mansoni isolates in Swiss Webster mice that were subm
itted to treatment with the same drug. The experimental group with failure
of treatment showed higher mean number of surviving male worms when it was
compared to the group without failure of treatment. These date suggest the
possibility of resistance to oxamniquine.