Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape

Authors
Restifo, NP
Citation
Np. Restifo, Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape, NAT MED, 6(5), 2000, pp. 493-495
Citations number
31
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
NATURE MEDICINE
ISSN journal
10788956 → ACNP
Volume
6
Issue
5
Year of publication
2000
Pages
493 - 495
Database
ISI
SICI code
1078-8956(200005)6:5<493:NSFRTM>2.0.ZU;2-U
Abstract
Based on early studies, it was hypothesized that expression of Fas ligand ( FasL) by tumor cells enabled them to counterattack the immune system, and t hat transplant rejection could be prevented by expressing FasL on transplan ted organs. More recent studies have indicated that the notion of FasL as a mediator of immune privilege needed to be reconsidered, and taught a valua ble lesson about making broad conclusions based on small amounts of data.