Intravenous immunoglobulin (IVIg) for the treatment of birdshot retinochoroidopathy

Intravenous polyclonal immunoglobulin (IVIg) treatment has been successfull y used in a number of autoimmune conditions. Birdshot retinochoroidopathy ( BRC) is a bilateral autoimmune posterior uveitis which, in its progressive form, frequently requires immunosuppressive therapy. We report a clinical s tudy aimed at determining the tolerance and efficiency of IVIg treatment in patients with active BRC. The study was conducted in an open manner. Eight een patients were included. The initial visual acuity (VA) was less than or equal to 20/30 in 26 eyes, 20/25 in five eyes, and 20/20 in five eyes. IVI g was given as sole treatment at 1.6 g/kg every four weeks for six months, followed by injections of 1.2-1.6 g/kg at six to eight-week intervals. The mean follow-up was 39 months, ranging between 12 and 53 months. The results showed that the final VA of the 26 eyes with an initial VA of less than or equal to 20/30 was increased by two lines or more in 14 eyes (53.8%) and d ecreased in two (7.7%). Of the five eyes with an initial VA of 20/25, four had improved to 20/20 and one remained stable. Of the five eyes with an ini tial VA of 20/20, four remained stable and one deteriorated to 20/25. When present, macular edema was improved in half of the eyes on fluorescein angi ography. Benign side effects were observed in 12 patients: moderate transie nt arterial hypertension (7), headache (6), eczematous lesions (6), and hyp erthermia (4). The results suggest that IVIg may represent a safe alternati ve therapy for patients with BRC.