Aldol reaction under solvent-free conditions: Highly stereoselective synthesis of 1,3-amino alcohols

Authors
Loh, TP Huang, JM Goh, SH Vittal, JJ
Citation
Tp. Loh et al., Aldol reaction under solvent-free conditions: Highly stereoselective synthesis of 1,3-amino alcohols, ORG LETT, 2(9), 2000, pp. 1291-1294
Citations number
22
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
9
Year of publication
2000
Pages
1291 - 1294
Database
ISI
SICI code
1523-7060(20000504)2:9<1291:ARUSCH>2.0.ZU;2-2
Abstract
A method for the highly stereoselective synthesis of 1,3-amino alcohols bas ed on the indium trichloride-catalyzed Mukaiyama aldol reaction of keto est er (R,S)-1 under solvent-free conditions has been developed, The high selec tivity observed can be explained on the basis of the shielding of one face by a remote substituent.