Vaccination against cysticercosis and hydatid disease

Infections with the larval stages of taeniid cestode parasites cause substa ntial human morbidity as well as economic losses in domestic livestock spec ies. Despite ongoing efforts around the world, few countries have been able substantially to reduce or eradicate these infections through the use of a nthelmintics and lifestyle changes. Vaccines offer an additional potential tool to assist with the control of parasite transmission. Here, Marshall Li ghtowlers and colleagues review the substantial progress that has been made towards developing practical vaccines against hydatid disease in sheep and cysticercosis in sheep and cattle. Recombinant antigens have been used to induce more than 90% protection against challenge infections. Such success in animals encourages investigation of the potential use of vaccines in hum ans to prevent hydatid disease arising from infection with Echinococcus gra nulosus and cysticercosis from infection with Taerua solium.