Neoplastic processes involving the infratemporal fossa may originate from t
he tissues in the region, but more often are the result of extension from n
eighboring structures. Metastatic lesions located in the region are rarely
encountered. Because of its concealed localization, tumors may remain unnot
iced for some time. Clinical signs and symptoms often arise late, are insid
ious, and may be mistakenly attributed to other structures. The close proxi
mity of the area to the intracranial structures, the orbit, the paranasal s
inuses, the nasopharynx, and the facial area demands careful planning of su
rgical excision and combined procedures may be called for. Modern imaging t
echniques have made three-dimensional visualization of the extent of the pa
thology possible. Treatment depends on the histopathology and staging of th
e tumor. Several surgical approaches have been developed over the years. Ra
dical tumor excision with preservation of the quality of life remain the ul
timate goal for those tumors where surgery is indicated. Experience over a
decade with various pathologies is presented.