Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases

Authors
Evans, GB Furneaux, RH Gainsford, GJ Schramm, VL Tyler, PC
Citation
Gb. Evans et al., Synthesis of transition state analogue inhibitors for purine nucleoside phosphorylase and N-riboside hydrolases, TETRAHEDRON, 56(19), 2000, pp. 3053-3062
Citations number
37
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
19
Year of publication
2000
Pages
3053 - 3062
Database
ISI
SICI code
0040-4020(20000505)56:19<3053:SOTSAI>2.0.ZU;2-Q
Abstract
Syntheses of the 'Immucillins', potent aza-C-nncleoside inhibitors of purin e nucleoside phosphorylase are reported as well as those of 5-deoxy-, 5-deo xyfluoro- and 2-deoxy- analogues and others having modified bases. (C) 2000 Elsevier Science Ltd. All rights reserved.