Staphylococcus lugdunensis is a recently described coagulase negative staph
ylococcal species involved in human infections. Endocarditis caused by Stap
hylococcus lugdunensis has been reported rarely: fewer than 50 cases have b
een described so far. The infection is frequently complicated by embolic ev
ents and carries a high mortality rate. We report a case of endocarditis du
e to Staphylococcus lugdunensis in which the native mitral and aortic valve
s were infected. The bacterium was isolated on cultures from the aortic and
mitral vegetations. Appropriate medical and surgical treatment led to a go
od outcome of the infection. At 6-year follow-up, there was no evidence of
recurrence, and the patient showed good functional recovery. He was in New
York Heart Association functional class I.