A genetic programme for neuronal connectivity

Authors
Ghysen, A Dambly-Chaudiere, C
Citation
A. Ghysen et C. Dambly-chaudiere, A genetic programme for neuronal connectivity, TRENDS GEN, 16(5), 2000, pp. 221-226
Citations number
49
Categorie Soggetti
Molecular Biology & Genetics
Journal title
TRENDS IN GENETICS
ISSN journal
01689525 → ACNP
Volume
16
Issue
5
Year of publication
2000
Pages
221 - 226
Database
ISI
SICI code
0168-9525(200005)16:5<221:AGPFNC>2.0.ZU;2-L
Abstract
What is the nature of the genetic programme that allows neurons to extend t heir axons and connect to other neurons with a high degree of specificity? Work on the sensory neurons of the fly has shown how the control of neurona l identity is embedded in the general developmental programme of the organi sm. The ongoing analysis of pathfinding mutants suggests plausible mechanis ms for the translation of neuronal identity into axonal behaviour.