Citation
K. Kono et al., Serum level of HER-2/neu in patients with gastric cancer: Correlation withHER-2/neu overexpression in gastric carcinoma tissue, TUMOR BIOL, 21(3), 2000, pp. 139-144
Citations number
26
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
TUMOR BIOLOGY
ISSN journal
10104283
→ ACNP
Volume
21
Issue
3
Year of publication
2000
Pages
139 - 144
Database
ISI
SICI code
1010-4283(200005/06)21:3<139:SLOHIP>2.0.ZU;2-E
Abstract
Serum HER-2/neu (c-erbB-2) levels in patients with gastric cancer were eval
uated by an enzyme-linked immunosorbent assay and tissue levels of HER-2/ne
u in the same cohort were determined by immunohistochemistry. Nine (16%) of
57 gastric carcinomas had an overexpression of HER-2/neu detected immunohi
stochemically. Of these 9 patients, 6 had elevated serum HER-2/neu levels,
while 45 of 48 tissue samples with negative staining exhibited normal serum
HER-2/neu levels. These results indicated that overall accuracy, positive
predictive value, and negative predictive values of their serum measurement
s were 89, 67 and 94%, respectively. Serum levels of HER-2/neu were correla
ted with tissue overexpression of HER-2/neu in patients with gastric cancer
. Copyright (C) 2000 S. Karger AG, Basel.