Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark

Authors
de Souza, MM Bittar, M Cechinel, V Yunes, RA Messana, I Delle Monache, F Ferrari, F
Citation
Mm. De Souza et al., Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark, Z NATURFO C, 55(3-4), 2000, pp. 256-260
Citations number
15
Categorie Soggetti
Biochemistry & Biophysics
Journal title
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
ISSN journal
09395075 → ACNP
Volume
55
Issue
3-4
Year of publication
2000
Pages
256 - 260
Database
ISI
SICI code
0939-5075(200003/04)55:3-4<256:APOMAP>2.0.ZU;2-J
Abstract
The antinociceptive effects of morusin (1), the main prenylflavonoid presen t in the Morus nigra root barks have been investigated in classical models of pain in mice. The results showed that 1 exhibits a promising antinocicep tive or analgesic profile by the intraperitoneal route, being more potent t han some standard drugs used as reference. The mechanism by which the morus in exerts antinociceptive activity still remains undetermined, but our resu lts strongly suggest that it involves the participation of the opioid syste m.