Citation
As. Galabov et al., Inhibitory effect of a cyclic urea derivative on rubella virus replication, Z NATURFO C, 55(3-4), 2000, pp. 292-294
Citations number
5
Categorie Soggetti
Biochemistry & Biophysics
Journal title
ZEITSCHRIFT FUR NATURFORSCHUNG C-A JOURNAL OF BIOSCIENCES
ISSN journal
09395075
→ ACNP
Volume
55
Issue
3-4
Year of publication
2000
Pages
292 - 294
Database
ISI
SICI code
0939-5075(200003/04)55:3-4<292:IEOACU>2.0.ZU;2-I
Abstract
1-(4-Morpholinomethyl)-tetrahydro-2(1H)-pyrimidinone (mopyridone) exhibited
a marked activity against rubella virus (Judith and RA27/3 strains), a MIC
50 value of 0.9 mu M and selectivity ratio of 557.7 been found in the case
of Judith strain. These data, in addition to the previous ones about its an
ti-alphavirus effects suggest the compound to be considered as a broad spec
trum inhibitor of togavirus replication.