Vg. Florea et al., Relation of changes over time in ventricular size and function to those inexercise capacity in patients with chronic heart failure, AM HEART J, 139(5), 2000, pp. 913-917
Citations number
27
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Background we studied the direction and magnitude of changes in left ventri
cular (LV) cavity size and mass over time and whether these changes were re
lated to those in exercise performance in patients with chronic heart failu
re (CHF).
Methods and Results The study group war compared of 59 patients (55 men age
d 58 +/- 10 years) with CHF and IV end-diastolic diameter (EDD) >55 mm. All
underwent echocardiography and a treadmill cardiopulmonary exercise test w
ithin a 4-week interval (baseline) and again after a period of greater than
or equal to 4 months (median of 14 months). At baseline, the group as a wh
ole had moderate to severe LV dysfunction with an EDD of 70 +/- 9 mm, end-s
ystolic diameter (ESD) of 60 +/- 11 mm, and LV mass of 500 +/- 200 EI. The
mean peak oxygen consumption ((V) over dot o(2), 18 +/- 6 mL/kg per minute)
was unrelated to LV cavity size or mass. EDD increased in 37 (63%) of the
patients and fell in 22 (37%) patients from the initial to the second test.
The absolute magnitude of changes over time averaged 7 mm for EDD, 125 g f
or mass, and 6 mL/kg per minute for peak (V) over dot o(2). Changes in LV s
ize and mass per year were significantly related to those in peak (V) over
dot o(2) (r = -0.49 for EDD, r = -0.56 for ESD, and r = -0.44 for IV mass,
respectively, all P <.001) and ventilatory response to exercise (r = 0.60,
r = 0.58, and r = 0.72 for EDD, ESD, and LV mass; respectively, all P <.001
).
Conclusions Changes over lime in objective measures of LV dimensions and ma
ss, in patient:, With CHF are significantly related to those in exercise ca
pacity and respiratory efficiency.