MANGANESE DEFICIENCY AFFECTS HDL1 AND HDL2 COMPOSITION IN RATS

The effects of manganese deficiency on high density lipoprotein subcla ss (HDL1 and HDL2) composition was assessed. Weanling male Sprague-Daw ley rats were fed a manganese-deficient (0.48 mg/kg) or a manganese-ad equate (90 mg/kg) diet. After 15 weeks, mean body weights, liver manga nese, plasma cholesterol and protein, and HDL2 cholesterol and protein were significantly lower in the deficient group of rats. Plasma and H DL2 phospholipids and triglycerides and HDL1 protein and lipids were n ot significantly affected by manganese deficiency. The percentage of a polipoprotein A-I in HDL1 was significantly greater (P < 0.05) in mang anese-deficient rats, while the HDL2 apolipoprotein composition was th e same in both groups. The apparent molecular weights of apolipoprotei ns were not affected by manganese deficiency in either HDL subclass. ( C) 1997 Elsevier Science Inc.