Ge. Davis et al., Regulation of tissue injury responses by the exposure of matricryptic sites within extracellular matrix molecules, AM J PATH, 156(5), 2000, pp. 1489-1498
Citations number
106
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
Extracellular matrix (ECM) is known to provide signals controlling cell sha
pe, migration, proliferation, differentiation, morphogenesis, and survival.
Recent data shows that some of these signals are derived from biologically
active cryptic sites within matrix molecules (matricryptic sites) that are
revealed after structural or conformational alteration of these molecules.
We propose the name, matricryptins, for enzymatic fragments of ECM contain
ing exposed matricryptic sites. Mechanisms regulating the exposure of matri
cryptic sites within ECM molecules include the major mechanism of enzymatic
breakdown as well as others including ECM protein multimerization, adsorpt
ion to other molecules, cell-mediated mechanical forces, and ECM denaturati
on. Such matrix alterations occur during or as a result of tissue injury, a
nd thus, the appearance of matricryptic sites within an injury site may pro
vide important new signals to regulate the repair process. Here, we review
the data supporting this concept and provide insight into why the increased
exposure of matricryptic sites may be an important regulatory step in tiss
ue responses to injury.