Determination of somatic mutant frequencies at glycophorin A and T-cell receptor loci for biodosimetry of acute and prolonged irradiation

Authors
Saenko, AS Zamulaeva, IA Smirnova, SG Orlova, NV Selivanova, EI Matveeva, NP Kaplan, MA Nugis, VY Nadezhina, NM Tsyb, AF
Citation
As. Saenko et al., Determination of somatic mutant frequencies at glycophorin A and T-cell receptor loci for biodosimetry of acute and prolonged irradiation, APPL RAD IS, 52(5), 2000, pp. 1145-1148
Citations number
10
Categorie Soggetti
Multidisciplinary
Journal title
APPLIED RADIATION AND ISOTOPES
ISSN journal
09698043 → ACNP
Volume
52
Issue
5
Year of publication
2000
Pages
1145 - 1148
Database
ISI
SICI code
0969-8043(200005)52:5<1145:DOSMFA>2.0.ZU;2-K
Abstract
Somatic mutant frequencies at glycophorin A (GPA) and T-cell receptor (TCR) loci were assessed. The dependence of the GPA mutant frequency on doses of acute and prolonged irradiation was shown. In the case of acute irradiatio n the GPA mutant frequency displayed a three-fold greater dose-related incr ease as compared to prolonged irradiation. A dose-dependent increase in the TCR variant frequency was found only in a group of subjects with recent ex posures. In Chernobyl clean-up workers the TCR mutant frequency was signifi cantly higher than in control non-irradiated individuals. (C) 2000 Elsevier Science Ltd. All rights reserved.