Cytogenetic features of leukaemias diagnosed in residents of areas contaminated after the Chernobyl nuclear accident

A comparison of chromosomal abnormalities in bone marrow leukaemic cells an d of stable and unstable aberrations in lymphocytes of patients with hemato logical malignancies who live in areas with or without contamination by the Chernobyl nuclear accident has been made using FISH and G-banding. Healthy residents of these areas comprised the control group. No systematic cytoge netic differences of leukaemic cells between patients from contaminated and uncontaminated areas were observed. Lymphocyte aberrations, however, were generally higher in all subjects from contaminated areas. Comparison has be en made with specific cytogenetic features of leukaemic cells and a high le vel of stable aberrations in lymphocytes of patients with secondary leukaem ias that had developed after chemo- and/or radio-therapy. (C) 2000 Elsevier Science Ltd. All rights reserved.