Single values of serum transferrin receptor and transferrin receptor ferritin index can be used to detect true and functional iron deficiency in rheumatoid arthritis patients with anemia
P. Suominen et al., Single values of serum transferrin receptor and transferrin receptor ferritin index can be used to detect true and functional iron deficiency in rheumatoid arthritis patients with anemia, ARTH RHEUM, 43(5), 2000, pp. 1016-1020
Objective, To elucidate the use of serum transferrin receptor (sTfR) to dis
tinguish between iron-deficiency anemia (IDA) and anemia of chronic disease
(ACD), and to establish an improved scheme to identify functional iron def
iciency (FID) in rheumatoid arthritis (RA) patients with anemia.
Methods, We studied 30 anemic RA patients whose iron status was confirmed b
y bone marrow examination and determination of the sTfR level, serum ferrit
in level, and sTfR-log ferritin index (TfR-F Index). All patients with dimi
nished or exhausted iron stores (n = 18) received oral iron supplementation
.
Results, Baseline values of sTfR and the TfR-F Index predicted the response
correctly in all patients who received supplementation treatment and were
normal in 10 of 11 patients with normal initial iron stores (ACD).
Conclusion, The results of this study elucidate the roles of sTfR and the T
fR-F Index in the differential diagnosis between IDA and ACD and provide di
rect evidence that these parameters are useful in detecting FID, irrespecti
ve of the concurrent iron storage status.