Synthesis and cytotoxic activity of N-[2-(dimethylamino)ethyl] carboxamidederivatives of benzofuro[2,3-b]quinoline, 6H-quinindoline, indeno[2,1-b] quinoline and [1] benzothieno[2,3-b] quinoline
Xy. Bu et al., Synthesis and cytotoxic activity of N-[2-(dimethylamino)ethyl] carboxamidederivatives of benzofuro[2,3-b]quinoline, 6H-quinindoline, indeno[2,1-b] quinoline and [1] benzothieno[2,3-b] quinoline, AUST J CHEM, 53(2), 2000, pp. 143-147
The acid precursors of the title compounds were prepared from methyl 2-amin
o-3-formylbenzoate (3), by Friedlander synthesis with o-methoxy- and o-nitr
o-phenylacetic acids, phenylpyruvic acid and benzo[b]thiophen-2-one, respec
tively. Except for the last example, cyclization of an initial 3-arylquinol
ine derivative was then required to give the tetracycle. Growth inhibition
properties of the carboxamides in a series of cancer cell lines were measur
ed for comparison with previous data for an isomeric series. In all cases,
the present set were found to be less active.