New and more potent antifungal disulfides

Authors
Baerlocher, FJ Baerlocher, MO Langler, RF MacQuarrie, SL Marchand, ME
Citation
Fj. Baerlocher et al., New and more potent antifungal disulfides, AUST J CHEM, 53(1), 2000, pp. 1-5
Citations number
22
Categorie Soggetti
Chemistry
Journal title
AUSTRALIAN JOURNAL OF CHEMISTRY
ISSN journal
00049425 → ACNP
Volume
53
Issue
1
Year of publication
2000
Pages
1 - 5
Database
ISI
SICI code
0004-9425(2000)53:1<1:NAMPAD>2.0.ZU;2-C
Abstract
From a design principle described in an earlier paper, a new series of subs tituted aryl methyl disulfides have been prepared and tested against Asperg illus niger and Aspergillus flavus. Methyl p-nitrophenyl disulfide is more potent (by an order of magnitude) than the fungitoxic natural product (CH3S CH2S)(2). With the present rationale in hand, one can anticipate which Poly carpamine is an effective antifungal agent.