In vivo electron spin resonance assessment of decay constant of nitroxyl radical in selenium-deficient rat

Authors
Matsumoto, K Endo, K Utsumi, H
Citation
K. Matsumoto et al., In vivo electron spin resonance assessment of decay constant of nitroxyl radical in selenium-deficient rat, BIOL PHAR B, 23(5), 2000, pp. 641-644
Citations number
37
Categorie Soggetti
Pharmacology & Toxicology
Journal title
BIOLOGICAL & PHARMACEUTICAL BULLETIN
ISSN journal
09186158 → ACNP
Volume
23
Issue
5
Year of publication
2000
Pages
641 - 644
Database
ISI
SICI code
0918-6158(200005)23:5<641:IVESRA>2.0.ZU;2-P
Abstract
In vivo reducing capacity and cytosolic glutathione peroxidase (GSH-Px) act ivity in liver homogenate were evaluated in 6 weeks old Se-deficient and no rmal rats. GSH-Px was significantly lower in Se-deficient rats than in norm al rats. In vivo reducing capacity in head and liver parts, estimated from in vivo signal decay of a nitrosyl spin probe using a low frequency (300 MH z) ESR spectrometer, was significantly decreased in Se-deficient rats, sugg esting a decrease of antioxidant capacity in Se-deficient rats.