Inhibition of protein phosphatases by Michael adducts of ascorbic acid analogues with alpha,beta-unsaturated carbonyl compounds

Authors
Witt, UG Schultz, JE Dolker, M Eger, K
Citation
Ug. Witt et al., Inhibition of protein phosphatases by Michael adducts of ascorbic acid analogues with alpha,beta-unsaturated carbonyl compounds, BIO MED CH, 8(4), 2000, pp. 807-813
Citations number
23
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
8
Issue
4
Year of publication
2000
Pages
807 - 813
Database
ISI
SICI code
0968-0896(200004)8:4<807:IOPPBM>2.0.ZU;2-A
Abstract
By investigating the stereospecific Michael reaction of derivatives of asco rbic acid with acrolein we obtained a novel class of protein Ser/Thr phosph atase inhibitors. The inhibitory effect of the Michael adducts was examined using the canonical protein phosphatases type 1, 2A and 2B. Of the isozyme s examined the type 1 isoform was strongly inhibited. (C) 2000 Elsevier Sci ence Ltd. All rights reserved.