A. Davidson et al., Magnetic resonance spectroscopy in the evaluation of neurotoxicity following cranial irradiation for childhood cancer, BR J RADIOL, 73(868), 2000, pp. 421-424
Citations number
22
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
In order to evaluate the role of proton MR spectroscopy (H-1-MRS) in the di
agnosis and assessment of long-term radiation-related neurotoxicity, 14 chi
ldren who had received cranial irradiation for the treatment of childhood l
eukaemia (n=6) or brain tumours (n=8) underwent H-1-MRS, MRI and neuropsych
ological assessment. Short-term effects at 2 months following treatment wer
e studied in a further three patients. MRI abnormalities were observed in n
ine patients. No statistically significant differences between patients and
controls (n=17) were seen in any of the calculated H-1-MRS metabolite rati
os, in any of the three patient groups. On multivariate logistic regression
analysis there was a correlation between the choline/water ratio and a low
IQ. It is concluded that any systematic radiation-induced changes in the H
-1 MRS metabolites must be below the detection threshold of this study.