Adenocarcinoma of sweat glands of the footpads was diagnosed in 2 cats. Cli
nical signs included lameness and swelling of multiple digits. Pulmonary me
tastasis was detected in one case. Diagnosis was based on histopathological
and immunohistochemical findings. Eccrine adenocarcinoma should be include
d in the differential diagnosis of footpads lesions in aged cats.