Background: This study identifies potential mediators of job strain ef
fects on health by determining whether psychosocial factors known to p
redict an increased risk of cardiovascular disease and all-cause morta
lity are higher among women who report high levels of job strain. Meth
ods: Measures of job strain and other psychosocial risk factors were o
btained in a sample of 152 female employees of a local corporation. Ca
nonical correlation and analyses of covariance were used to assess rel
ationships between job demands and decision latitude and other psychos
ocial risk factors. Results: A significant (P = .002) solution to the
canonical correlation analysis showed that high job demands and low de
cision latitude were correlated with a pattern of psychosocial factors
consisting of (1) increased levels of negative emotions like anxiety,
anger, depression, and hostility; (2) reduced levels of social suppor
t; and (3) a preponderance of negative compared with positive feelings
in dealings with coworkers and supervisors. This pattern was confirme
d by analyses of covariance that adjusted for demographic and specific
job characteristics. Conclusions: The canonical correlation analysis
results provide empirical support for the job strain construct. The mo
st important finding is that health-damaging psychosocial factors like
job strain, depression, hostility, anxiety, and social isolation tend
to cluster in certain individuals.