New cytotoxic butanolides from Lindera obtusiloba BLUME

Authors
Kwon, HC Baek, NI Choi, SU Lee, KR
Citation
Hc. Kwon et al., New cytotoxic butanolides from Lindera obtusiloba BLUME, CHEM PHARM, 48(5), 2000, pp. 614-616
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
48
Issue
5
Year of publication
2000
Pages
614 - 616
Database
ISI
SICI code
0009-2363(200005)48:5<614:NCBFLO>2.0.ZU;2-4
Abstract
Three new butanolides, 2-(1-methoxy-11-dodecenyl)-penta-2,4-dien-4-olide (1 ), (2Z,3S,4S)-2-(11-dodecenylidene)-3-hydroxy-4-methylbutanolide (2) and (2 E,3R,4R)-2-(11-dodecenylidene)-3-hydroxy-4-methoxy-4-methylbutanolide (3), were isolated from the stems of Lindera obtusiloba BLUME. Their chemical st ructures were assigned by spectroscopic evidence. They exhibited cytotoxici ty against cultured human tumor cell lines with their ED50 values ranging f rom 3.19 to 14.63 mu g/ml.