Diastereo-enantioseparation of novel gamma-lactamic derivatives on cellulose chiral stationary phases

This paper describes the enantiorecognition of 1-methy 1-3-hydroxy-5-aryl-2 -pyrrolidinonic systems by high-performance liquid chromatography using two chiral derivatized cellulose stationary phases (CSPs) operated in the norm al phase mode. According our results, the tris-(3,5-dimethylphenyl carbamat e) cellulose, Chiralcel(R) OD, is more suitable than the tris-(4-methyl-phe nylbenzoate), Chiralcel(R) OJ. On the first column, the resolution of the p yrrolidinonic compounds depends on the alcoholic modifier percentage. A pos sible solute-stationary phase recognition mechanism is discussed. The tempe rature and mobile phase composition have been considered to explain the dif ferent contribution for the enantiomeric resolution.