Kjk. Kanhai et al., Noninvasive monitoring of nonshunted pulmonary capillary blood flow in theacute respiratory distress syndrome, CRIT CARE M, 28(4), 2000, pp. 1059-1067
Objective: Noninvasive monitoring of nonshunted pulmonary capillary blood f
low, using the alveolar amplitude response technique (AART) in a porcine mo
del of the acute respiratory distress syndrome.
Design: Experimental animal study
Setting: University center for animal experiments
Interventions: In 12 mechanically ventilated pigs, the nonshunted pulmonary
capillary blood flow was varied by means of lung lavages and the applicati
on of positive end-expiratory pressure,
Measurements and Main Results: Nonshunted pulmonary capillary blood flow wa
s determined by AART, Cardiac output (determined by the thermodilution meth
od) corrected for venous admixture was used for comparison (r(2) varied bet
ween .58 and .94; p <.01), The trend in the development of nonshunted pulmo
nary capillary blood flow as measured with AART was in agreement with the t
rend detected by cardiac output corrected for venous admixture in 92% of al
l events.
Conclusions: We conclude that AART can be used to monitor changes in nonshu
nted pulmonary capillary blood flow in cases of acute respiratory distress
syndrome noninvasively and continuously.