Growth factor production, glomerular cell proliferation and glomerular extr
acellular matrix expansion are prominent features of mesangioproliferative
and crescentic glomerulonephritides. Recent studies have provided additiona
l insights into the mechanisms of mesangial cell proliferation and interact
ion with extracellular matrix, and have focused on selective interruption o
f relevant mediators of injury, Studies into mitogenic signalling and cell
cycle regulation in glomerular epithelial cells support a pathogenetic role
for growth factors and glomerular epithelial cell proliferation in focal s
egmental glomerulosclerosis, and possibly membranous nephropathy. A better
appreciation of growth factor pathways may lead to new treatment strategies
for human glomerulopathies, Curl Opin Nephrol Hypertens 9:217-223. (C) 200
0 Lippincott Williams & Wilkins.