S. Elgun et al., A potential role for arginase in recurrent infections and hypertrophy of tonsillar and adenoidal tissue, EUR ARCH OT, 257(3), 2000, pp. 158-160
Since arginase has been found to be an arginine-depleting and nitric oxide
synthase-regulating enzyme, the present study was devised to examine hypert
rophied and infected tonsil and adenoid arginase activity in relation to a
metabolic arginase-nitric oxide pathway and its association with disease pr
ocesses. Tissues were taken from 32 children undergoing adenotonsillectomy.
There was a statistically significant difference between the two tissue en
zyme activities, with tonsillar arginase activity being higher than the cor
responding adenoidal tissue (P < 0.005). This suggests a potential role for
tissue arginase activity as an outcome module and a contributing factor in
chronic recurrent infection and hypertrophy of tonsillar and adenoidal tis
sues.