Background Portal hypertensive gastropathy (PHG) is frequently found among
patients with hepatic cirrhosis and at present the only way to detect and f
ollow PHG is via endoscopy.
Objective To assess gastric and intestinal permeability and investigate its
relationship to endoscopic findings and indices of portal hypertension and
hepatic function.
Design and methods Thirty-one non-diabetic patients with hepatic cirrhosis
and PHG (PHG+) were studied and compared with 17 cirrhotic patients without
PHG (PHG-), All patients underwent endoscopy for the assessment of PHG and
Helicobacter pylori status, ultrasound determination of the diameters of s
pleen and portal vein, and, subsequently, an oral load of sucrose, lactulos
e, and mannitol. Sugar concentrations were determined in 6-h urine specimen
s and expressed as a percentage of the orally administered dose or as lactu
lose/mannitol ratio.
Results The urinary sucrose excretion was significantly elevated in patient
s with PHG compared to those without (PHG+, 0.20% +/- 0.03; PHG-, 0.07% +/-
0.01; P < 0.001). No difference was found for the small intestinal probes
lactulose and mannitol, Gastric sucrose permeability correlated positively
with the endoscopic lesion score (P < 0.001), but not with other parameters
of portal hypertension or hepatic function. H. pylori status did not influ
ence gastric permeability. The sensitivity of this test reached 100% for PH
G scores > 2.
Conclusions Gastric permeability to sucrose is increased in patients with P
HG, independently of the presence of H. pylori. Sucrose permeability may be
useful for the followup of patients with PHG. (C) 2000 Lippincott Williams
& Wilkins.