A facile solid-phase strategy for the synthesis of oligonucleotide-tetraphenylporphprin conjugates

Authors
De Napoli, L De Luca, S Di Fabio, G Messere, A Montesarchio, D Morelli, G Piccialli, G Tesauro, D
Citation
L. De Napoli et al., A facile solid-phase strategy for the synthesis of oligonucleotide-tetraphenylporphprin conjugates, EUR J ORG C, (6), 2000, pp. 1013-1018
Citations number
27
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
6
Year of publication
2000
Pages
1013 - 1018
Database
ISI
SICI code
1434-193X(200003):6<1013:AFSSFT>2.0.ZU;2-F
Abstract
A convenient solid-phase synthesis of oligonucleotides conjugated at the 3' -end with a tetraphenylporphyrin residue, by means of a new polymeric suppo rt bearing as a linker a lysine derivative, has been developed. A porphyrin linked 17-mer, designed for antisense experiments, has been prepared in go od yields, and its hybridization properties with a complementary DNA fragme nt evaluated by UV thermal analysis.