Citation
A. Leggio et al., New strategies for an efficient removal of the 9-fluorenylmethoxycarbonyl (Fmoc) protecting group in the peptide synthesis, EUR J ORG C, (4), 2000, pp. 573-575
Citations number
7
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X
→ ACNP
Issue
4
Year of publication
2000
Pages
573 - 575
Database
ISI
SICI code
1434-193X(200002):4<573:NSFAER>2.0.ZU;2-S
Abstract
The aluminium trichloride/toluene system is investigated as a novel, unusua
l and straightforward reagent for the removal of the 9-fluorenylmethoxycarb
onyl (Fmoc) protecting group in the solution peptide synthesis. This proced
ure avoids any undesired side reactions, such as the frequently observed in
version of the amino acid configuration.