Q. Yang et al., Adjusting for confounding due to population admixture when estimating the effect of candidate genes on quantitative traits, HUMAN HERED, 50(4), 2000, pp. 227-233
When analyzing the relationship between allelic variability and traits, a p
otential source of confounding is population admixture. An approach to adju
sting for potential confounding due to population admixture when estimating
the influence of allelic variability at a candidate gene is presented. The
approach involves augmenting linear regression models with additional regr
essors. Family genotype data are used to define the regressors, and inclusi
on of the regressors ensures that, even in the presence of population admix
ture, the estimates of the regression coefficients that parameterize the in
fluence of allelic variability on the trait are unbiased. The approach is i
llustrated through an analysis of the influence of apolipoprotein E genotyp
e on plasma low density lipoprotein cholesterol concentrations. Copyright (
C) 2000 S. Karger AG, Basel.