HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF QUININE IN RAT BIOLOGICAL-FLUIDS

Authors
CHMURZYNSKI L
Citation
L. Chmurzynski, HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF QUININE IN RAT BIOLOGICAL-FLUIDS, Journal of chromatography B. Biomedical sciences and applications, 693(2), 1997, pp. 423-429
Citations number
21
Categorie Soggetti
Chemistry Analytical","Biochemical Research Methods
Journal title
Journal of chromatography B. Biomedical sciences and applications → ACNP
ISSN journal
13872273
Volume
693
Issue
2
Year of publication
1997
Pages
423 - 429
Database
ISI
SICI code
0378-4347(1997)693:2<423:HLDOQI>2.0.ZU;2-P
Abstract
A high-performance liquid chromatographic (HPLC) method with ultraviol et detection for the determination of quinine in rat biological fluids is described. Due to its selectivity and sensitivity, the proposed me thod can be used in the case of such rat biological fluids as cerebros pinal fluid (CSF) and perilymph for which the accessible volumes are l imited to 100 mu l and 10 mu l, respectively. Consequently, the assay method has been applied to the measurements of quinine concentration i n rat plasma, CSF and perilymph samples.