Efficacy of dietary protein against monocrotophos toxicity on some carbohydrate metabolic enzymes in rats

A study on carbohydrate metabolic hepatic enzymes was conducted to establis h the beneficial effect of dietary protein in alleviating the toxic stress of a single or repeated intubation of monocrotophos (2 mg/kg body weight) i n rats maintained on formulated isoenergetic diets under normal, protein de ficient and protein supplemented dietary conditions at 20 and 5% protein le vels. Acute and chronic administration of organophosphate at varying interv als induced variable responses. An accelerated rate of anaerobic glycolysis with a concomitant decreased rate of gluconeogenesis was indicated in maln ourished rats after acute dosage. Chronic monocrotophos poisoning induced increased energy demand in normal r ats. In protein deficient rats, the rate of glycogenolysis and glycolysis e levated to meet the primary stress response; the activity of gluconeogenic enzymes also got stimulated. However, the animals were able to counteract t he toxicity of pesticide on hepatic enzymes, when fed on high protein diet.