Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia

Authors
Kristiansen, JE Hansen, JB
Citation
Je. Kristiansen et Jb. Hansen, Inhibition of HIV replication by neuroleptic agents and their potential use in HIV infected patients with AIDS related dementia, INT J ANT A, 14(3), 2000, pp. 209-213
Citations number
46
Categorie Soggetti
Microbiology
Journal title
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
ISSN journal
09248579 → ACNP
Volume
14
Issue
3
Year of publication
2000
Pages
209 - 213
Database
ISI
SICI code
0924-8579(200004)14:3<209:IOHRBN>2.0.ZU;2-W
Abstract
A series of neuroleptic agents and their structural isomers have been teste d as inhibitors of HIV-replication. At non-toxic concentrations, cis (Z)- a nd trans (E)-flupentixol and several derivatives of the 5HT-uptake-inhibito rs paroxetine and femoxetine, inhibit HIV-1 replication. The findings indic ated that these compounds could be used in combination with other anti-retr oviral therapy in HIV-1 infected patients with AIDS-related dementia. (C) 2 000 Elsevier Science B.V, and International Society of Chemotherapy. All ri ghts reserved.