Familial amyloid polyneuropathy type I complicated by chronic glaucoma: 3 cases

Purpose: We report 3 cases of familial amyloid polyneuropathy type 1 (FAP) with amyloid infiltration of the vitreum and glaucoma. Patients and methods: We reviewed the records of three patients, 2 females and one male, aged 41, 47 and 83 years respectively. The 3 patients had fam ilial amyloid polyneuropathy type 1 with vitreous infiltration and open ang le glaucoma. The two women underwent a liver graft four years earlier. Vitr ectomy allowed confirmation of the diagnosis in the 83-year-old patient. Tw o patients underwent trabeculectomy, histological analysis of the iris and the trabeculum was obtained for one patient. Results: The tree patients presented a polyneuropathy, Vitreous infiltratio n and open angle glaucoma. Results of light microscopy of the iris and the trabeculum showed amyloid deposits in the iris and the trabecular meshworks . Conclusion: Familiar amyloid polyneuropathy is a hereditary disease which m ay have a wide range of ocular manifestations. Glaucoma is among the most s erious complications of familial amyloid polyneuropathyt.