Adsorption behavior and prediction of the band profiles of the enantiomersof 3-chloro-1-phenyl-1-propanol - Influence of the mass transfer kinetics

The single-component and competitive adsorption isotherms of the enantiomer s of 3-chloro-1-phenyl-1-propanol were measured by frontal analysis. The st ationary phase was a cellulose tribenzoate coated on silica, the mobile pha se an n-hexane-ethyl acetate (95:5) solution. The adsorption data measured fitted well to the Langmuir isotherm model. The band profiles of single com ponents and of their mixtures were calculated using the equilibrium-dispers ive model. These profiles were found to match quite satisfactorily the expe rimental band profiles. However, the agreement between calculated and exper imental band profiles was significantly improved when a more complex model taking into account the mass transfer kinetics was used. The mass transfer rate coefficients, k(f), for both single components were determined by usin g the transport-dispersive model of chromatography. The coefficients obtain ed were used to predict the band profiles of mixtures of the two enantiomer s to good agreement. (C) 2000 Elsevier Science BN. All rights reserved.