Solid phase synthesis of purines from pyrimidines

In this paper the solid phase synthesis of various substituted purines is d escribed starting from 4,6-dichloro-5-nitropyrimidine, The 4,6-dichloro-5-n itropyrimidine was coupled to Rink amide resin followed by displacement of the second chloride by an amino compound. Reduction of the nitro compound p roved to be problematic but was achieved using lithium aluminum hydride/alu minum trichloride. The diamines (13) were then elaborated to purines by thr ee different routes.