Ketamine abusers presenting to the emergency department: A case series

Ketamine hydrochloride, familiar to emergency physicians as a dissociative anesthetic, has been abused as a hallucinogen for almost 30 years, The drug produces effects similar to those of phencyclidine but with a much shorter duration of effect. Since 1996, an increasing number of patients have pres ented to Connecticut Emergency Departments (EDs) after the intentional abus e of ketamine, Because the medical literature contains almost no informatio n on the consequences of ketamine abuse, we have compiled a series of ketam ine abusers presenting to the ED. Among the 20 patients in this series, com mon presenting complaints included anxiety, chest pain, and palpitations. T achycardia was the most common physical examination finding, Nystagmus, a c ommon finding after phencyclidine use, was seen in only three cases, The mo st frequent complications after ketamine abuse were severe agitation and rh abdomyolysis. The symptoms of ketamine intoxication appear to be short-live d, with 18 of the 20 patients discharged from the ED within 5 h of presenta tion. Emergency physicians should include ketamine in the differential diag nosis of drug- or toxin-induced hallucinations. Methods for detecting this drug in biologic fluids are reviewed as are treatment recommendations for m anaging the patient who presents to the ED after abusing ketamine, (C) 2000 Elsevier Science Inc.