Unexpected substituent effect in the stereoselective synthesis of trifluoromethyl group containing cyclopropane lactones

Authors
Faigl, F Finta, Z Hell, Z Kovesdi, I Toke, L
Citation
F. Faigl et al., Unexpected substituent effect in the stereoselective synthesis of trifluoromethyl group containing cyclopropane lactones, J FLUORINE, 103(2), 2000, pp. 117-121
Citations number
11
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF FLUORINE CHEMISTRY
ISSN journal
00221139 → ACNP
Volume
103
Issue
2
Year of publication
2000
Pages
117 - 121
Database
ISI
SICI code
0022-1139(200005)103:2<117:USEITS>2.0.ZU;2-Z
Abstract
Methyl or phenyl substitution in the allylic position of malonic esters of (E)-3-phenyl-3-trifluoromethyI-2-propen-1-ol resulted in unexpected and unp recedented stereospecific formation of the corresponding cyclopropane lacto ne derivatives by a multistep reaction with iodine in the presence of potas sium carbonate and phase transfer catalyst. (C) 2000 Elsevier Science S.A. All rights reserved.