Mbm. De Azevedo et al., Violacein/beta-cyclodextrin inclusion complex formation studied by measurements of diffusion coefficient and circular dichroism, J INCL P MA, 37(1-4), 2000, pp. 67-74
Citations number
41
Categorie Soggetti
Chemistry
Journal title
JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
The formation of inclusion compounds between violacein and beta-cyclodextri
n was studied by diffusion and circular dichroism measurements. The present
work was undertaken to explore the feasibility of the beta-cyclodextrin in
reducing the toxicity and enhancing the antitumoral efficacy of violacein
by forming an inclusion complex. The results of the two experiments are in
good agreement, suggesting the formation of 1 : 1 and 1 : 2 complexes. The
diffusion coefficient measurements enabled estimates of the sizes of the co
mplexes involved. From the circular dichroism and computational calculation
s it was possible to view a preference for inclusion of the most polar part
of the molecule to form a 1 : 2 inclusion complex. We expect that this wor
k proves the potential of these techniques to determining complex stoichiom
etry.