Selectively monomodified cyclodextrins. Synthetic strategies

;Monomodifications of cyclodextrins to give selectively 2-, 3-, or 6-substi tuted product is a challenging task because of the number of hydroxyl group s that can potentially react with the incoming reagent. The principles and the methods involved in manipulations of the differences in the chemistry o f these hydroxyl groups to control the outcome of an electrophilic reaction with them to produce monoalkylated (ether-linkaged) cyclodextrin derivativ es are discussed and illustrated.