EFFECTS OF CALORIC-INTAKE ON ANTICANCER THERAPY IN RATS WITH VALINE-DEPLETED AMINO-ACID IMBALANCE

Valine-depleted amino acid imbalance solution markedly inhibits tumor growth bus causes fatty liver as a side effect. However, much remains unknown about the mechanism of the development of fatty liver. Valine- depleted amino acid imbalance solution containing various concentratio ns of calories was administered to tumor-bearing mts for four days by means of total parenteral nutritional methods to investigate the inter action of caloric intake and the development of fatty liver. Compared with the total parenteral nutrition control group the triglyceride con tent of the liver rose significantly in the group given valine-deplete d amino acid imbalance solution with an increase in caloric intake. Pl asma total protein and albumin significantly decreased. The very-low-d ensity lipoprotein concentration in serum was also significantly lower than that in the control group. Valine-depleted amino acid imbalance caused hypoproteinemia, suggesting a fall in synthesis of apolipoprote ins in the liver indispensable for lipid release. Along with the incre ase in the total caloric intake, triglyceride synthesis in the liver i ncreased, resulting in augmentation of fatty content of the liver, pro bably because of the decreased lipid release.