The use of near-infrared spectroscopy to monitor the mobility of water within the sarafloxacin crystal lattice

Near-infrared spectroscopy (NIRS) is proposed as a technique to study the m obility of water within the sarafloxacin crystal lattice. An investigation of two samples of sarafloxacin revealed that NIRS can distinguish between a cceptable and unacceptable batches for formulation purposes. X-ray powder d iffraction (XRPD), mid-infrared (mid-IR) spectroscopy, differential scannin g calorimetry (DSC) and thermogravimetric analysis (TGA) could not detect a ny differences between the two samples. NIRS detected differences in the lo cation or orientation of the water molecules within the crystal lattices. ( C) 2000 Elsevier Science B.V. All rights reserved.