Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue

Authors
Grivel, JC Penn, ML Eckstein, DA Schramm, B Speck, RF Abbey, NW Herndier, B Margolis, L Goldsmith, MA
Citation
Jc. Grivel et al., Human immunodeficiency virus type 1 coreceptor preferences determine target T-cell depletion and cellular tropism in human lymphoid tissue, J VIROLOGY, 74(11), 2000, pp. 5347-5351
Citations number
14
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
74
Issue
11
Year of publication
2000
Pages
5347 - 5351
Database
ISI
SICI code
0022-538X(200006)74:11<5347:HIVT1C>2.0.ZU;2-1
Abstract
The present study sought to determine how usage of coreceptors by human imm unodeficiency virus type 1 dictates cell tropism and depletion of CD4(+) T cells in human lymphoid tissues cultured ex vivo. We found that coreceptor preferences control the marked, preferential depletion of coreceptor-expres sing CD4(+) lymphocytes. In addition, there was a strong, but not absolute, preference shown by CXCR4-using strains for lymphocytes and by CCR5-using strains for macrophages.