An enzyme-linked immunosorbent assay (ELISA) and a serum neutralization (SN
) test were developed to measure serum antibodies against the adenovirus ca
using hemorrhagic disease in free-ranging and captive experimentally-infect
ed black-tailed deer (Odocoileus hemionus columbianus) in California (USA).
There was a strong (rho = 0.874) and significant (P < 0.0001) correlation
between ELISA and SN titers, although the SN assay was more sensitive than
the ELISA.