In this article the pharmacokinetic quality of antibacterial agents in fish
has been reviewed, Oxytetracycline, and quinolones have been two of the mo
st frequently used antibacterial substances in treatment of fish diseases.
The use of another group of drugs is limited because of their efficacy, phy
sico-chemical properties and human safety. In contrast to mammalian and oth
er species, the environmental impact affects the pharmacokinetic parameters
of anti-infective agents in fish. The influence of water temperature and s
alinity on the correlation between medications and ectothermic organisms ha
ve been emphasised. Generally, lower bioavailabilities and longer eliminati
on times in fish have been established in contrast to other food-producing
animals.