Pharmacokinetic quality of antibacterial medications for fish

In this article the pharmacokinetic quality of antibacterial agents in fish has been reviewed, Oxytetracycline, and quinolones have been two of the mo st frequently used antibacterial substances in treatment of fish diseases. The use of another group of drugs is limited because of their efficacy, phy sico-chemical properties and human safety. In contrast to mammalian and oth er species, the environmental impact affects the pharmacokinetic parameters of anti-infective agents in fish. The influence of water temperature and s alinity on the correlation between medications and ectothermic organisms ha ve been emphasised. Generally, lower bioavailabilities and longer eliminati on times in fish have been established in contrast to other food-producing animals.